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St. Michael's Hospital Laboratory
Test Directory



Order Name LDH
Athena Orderable:
LDH-S [amgw]
Revision Date 09/04/2020
Test Name Methodology LOINC Code
Specimen Specimen Volume (min) Specimen Type Specimen Container Transport Environment
Preferred 1.0 mL (0.5 mL) Plasma Lithium Heparin PST (Light Green Top) Refrigerated
Alternate 1 1.0 mL (0.5 mL) Plasma Lithium Heparin (Dark Green Top / No-Gel) Refrigerated
Alternate 2 1.0 mL (0.5 mL) Serum Clot Activator SST Refrigerated
Alternate 3 1.0 mL (0.5 mL) Serum Clot Activator (Red Top, No-Gel) Refrigerated
Testing Schedule 24 hr 
Expected TAT 1 hr  
Clinical Use Lactate dehydrogenase (LD) is present in the cytoplasm of all cells in the body. The concentration of LD in tissues is several hundred-fold higher than in serum or plasma and even a small amount of tissue damage can lead to an elevation in LD activity. This makes LD especially useful in the diagnosis and monitoring of disease states where tissue turnover is accelerated such as the liver, cardiac muscle, skeletal muscle, kidneys, and erythrocytes.
LD is elevated in myocardial or pulmonary infarction, leukemias, hemolytic anemias, non-viral hepatitis, sickle cell disease, lymphoma, renal infarction, acute pancreatitis and any condition that results in the leaking of cytoplasm. It is moderately elevated in cirrhosis, obstructive jaundice, renal disease, skeletal muscle diseases, neoplastic diseases and congestive heart failure. LD is markedly elevated in megaloblastic and pernicious anemia, metastatic carcinoma, viral hepatitis, shock, hypoxia and extreme hyperthermia. 
Rejection Criteria Specimens with >1+ hemolysis are unacceptable. 
CPT Code(s) 83615
Lab Section Laboratory - Chemistry