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St. Michael's Hospital Laboratory
Test Directory


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LACTOFERRIN DETECTION

Order Name LACTSO
Athena Orderable:
Lactoferrin-Stool [amgw]
Revision Date 09/04/2020
Test Name Methodology LOINC Code
LACTOFERRIN DETECTION
Enzyme Immunoassay 40703-1 
SPECIMEN REQUIREMENTS
Specimen Specimen Volume (min) Specimen Type Specimen Container Transport Environment
Preferred 1 mL/1 g Stool, Random Sterile Screwtop Container Refrigerated
Instructions
RML test code: 6002550
Click here to view information on the RML website.
GENERAL INFORMATION
Testing Schedule M-F at Reference facility  
Expected TAT 1-3 days  
Clinical Use Human lactoferrin, a major component of leukocytes, is present during an inflammatory response. Diarrheal diseases can be classified into inflammatory and non-inflammatory diarrhea. Non-inflammatory diarrheas include those caused by viruses and most parasites and are for the most part, effectively treated with simple oral rehydration therapy. Inflammatory diarrheas tend to be more serious and need to be followed up by more extensive testing. In inflammatory diarrheas, fecal leukocytes are found in the stool in large numbers. Pathogens such as Shigella, Salmonella, Campylobacter and Clostridium difficile are example of organisms that may cause an inflammatory response.

This test may also help distinguish between inflammatory bowel disease such as ulcerative colitis and Crohn’s disease, and active irritable bowel syndrome, which does not cause intestinal inflammation. The fecal lactoferrin test has an advantage over the determination of fecal leukocytes by microscopy. The microscopy method has disadvantages such as no standardization and degradation of the cells in the stool by lysis during storage. Lactoferrin is very stable and is not degraded during infections by the toxins of pathogens such as C. difficile. A positive test indicates elevated levels of lactoferrin released from fecal leukocytes as a marker of intestinal inflammation. 
Rejection Criteria Preservatives or Formalin is Not Acceptable.
Stool from Breast Fed infants is also Not Acceptable. 
Test Aliases Lactoferrin for IBD
Lactoferrin, Stool
CPT Code(s) 83630
Lab Section Reference Lab